Honda I, Tokuda H, Kozuka M, Yoneyama K, Nishino H, Iwashima A, Shibagaki M, Noma M, Takahashi N, Yoshida S
Life Science Research Laboratory, Japan Tobacco Inc., Yokohama.
Cancer Lett. 1991 Aug;59(2):83-8. doi: 10.1016/0304-3835(91)90170-m.
Inhibitory effects of a series of 3-nitro-2,4,6-trihydroxybenzamides on Epstein-Barr virus early antigen (EBV-EA) induction were examined using Raji cells. Some of the tested compounds showed highly inhibitory activity, the N-octyl amide derivative being the most active among them. These results suggest the possibility that 3-nitro-2,4,6-trihydroxybenzamides might be listed as novel inhibitors of tumor promotion.
使用拉吉细胞检测了一系列3-硝基-2,4,6-三羟基苯甲酰胺对爱泼斯坦-巴尔病毒早期抗原（EBV-EA）诱导的抑制作用。一些受试化合物表现出高度的抑制活性，其中N-辛基酰胺衍生物活性最高。这些结果表明3-硝基-2,4,6-三羟基苯甲酰胺有可能被列为新型肿瘤促进抑制剂。
