Honda I, Tokuda H, Kozuka M, Yoneyama K, Nishino H, Iwashima A, Shibagaki M, Noma M, Takahashi N, Yoshida S
Life Science Research Laboratory, Japan Tobacco Inc., Yokohama.
Cancer Lett. 1993 Jan 15;68(1):1-5. doi: 10.1016/0304-3835(93)90212-r.
The inhibitory effects of two series of 3-nitrophloroglucinecarboxylic acid derivatives, 3-nitro-2,4,6-trihydroxythiobenzamides (II) and 3-nitro-phloroglucinecarboxylates (III), on Epstein-Barr virus early antigen (EBV-EA) induction were examined using Raji cells. Some of them strongly inhibited the induction, N-nonyl and O-decyl derivatives being the most potent inhibitors among the thioamides and esters, respectively. These results suggest the possibility that these two 3-nitrophloroglucinecarboxylic acid derivatives may be listed as novel inhibitors of tumor promotion.
利用拉吉细胞检测了两个系列的3-硝基间苯三酚羧酸衍生物、3-硝基-2,4,6-三羟基硫代苯甲酰胺（II）和3-硝基间苯三酚羧酸盐（III）对爱泼斯坦-巴尔病毒早期抗原（EBV-EA）诱导的抑制作用。其中一些化合物强烈抑制该诱导作用，硫代酰胺类中的N-壬基衍生物和酯类中的O-癸基衍生物分别是最有效的抑制剂。这些结果表明，这两种3-硝基间苯三酚羧酸衍生物有可能被列为新型肿瘤促进抑制剂。
