职业和休闲时间的身体活动与不同部位结肠癌的风险
Occupational and leisure-time physical activity and risk of colon cancer by subsite.
作者信息
Zhang Yawei, Cantor Kenneth P, Dosemeci Mustafa, Lynch Charles F, Zhu Yong, Zheng Tongzhang
机构信息
Yale University School of Public Health, New Haven, Connecticut, USA.
出版信息
J Occup Environ Med. 2006 Mar;48(3):236-43. doi: 10.1097/01.jom.0000199521.72764.26.
OBJECTIVE
Studies of physical activity and colon cancer risk by anatomic site have provided inconsistent results.
METHODS
We analyzed data from a population-based case-control study conducted in Iowa involving 685 colon cancer cases and 2434 control subjects.
RESULTS
Among those who reported recreational activity more than twice per week, a 30% risk reduction of colon cancer was observed for all sites with a 40% risk reduction for cancer of the right colon. Occupational physical activity was also associated with a reduced risk of colon cancer. The risk was the lowest for those with both high occupational and recreational physical activity (odds ratio, 0.5; 95% confidence interval, 0.3-0.8).
CONCLUSIONS
Increased physical activity was inversely associated with colon cancer risk. The inverse associations were stronger for the right than for the left colon.
目的
按解剖部位对体力活动与结肠癌风险进行的研究结果并不一致。
方法
我们分析了爱荷华州一项基于人群的病例对照研究的数据，该研究涉及685例结肠癌病例和2434名对照对象。
结果
在那些报告每周进行娱乐活动超过两次的人群中，所有部位结肠癌风险降低30%，右半结肠癌风险降低40%。职业体力活动也与结肠癌风险降低有关。职业和娱乐体力活动水平都高的人群风险最低（比值比，0.5；95%置信区间，0.3 - 0.8）。
结论
体力活动增加与结肠癌风险呈负相关。右半结肠的负相关比左半结肠更强。
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