Appl Environ Microbiol. 1995 Jun;61(6):2159-65. doi: 10.1128/aem.61.6.2159-2165.1995.
2,3-, 2,4-, 2,5-, 3,4-, and 3,5-dimethylphenols were cometabolized by 2,4-dichlorophenoxyacetate-grown Alcaligenes eutrophus JMP 134 or the constitutive derivative JMP 134-1 via the ortho pathway into dimethylmuconolactones as dead-end products. Formation of two distinct lactones from 3,4-dimethylphenol is indicative of 2- as well as 6-hydroxylation. Induction of the meta-cleavage pathway by 2,3- and 3,4-dimethylphenols resulted in growth and no accumulation of products. In contrast, 3,5-dimethylphenol is not metabolized by the meta-cleavage pathway.
2,3-、2,4-、2,5-、3,4- 和 3,5-二甲苯酚可通过 2,4-二氯苯氧乙酸生长的 Alcaligenes eutrophus JMP 134 或组成型衍生物 JMP 134-1 经邻位途径代谢为二甲基戊烯酸内酯,成为无出路的产物。3,4-二甲苯酚可生成两种不同的内酯,表明存在 2-和 6-羟化作用。2,3-和 3,4-二甲苯酚诱导间位裂解途径,导致生长但不积累产物。相比之下,3,5-二甲苯酚不能通过间位裂解途径代谢。