抗疱疹病毒化合物2,3 - 二甲基 - 6(2 - 二甲基氨基乙基)-6H - 吲哚并-(2,3 - b)喹喔啉的作用机制。
The mechanism of action of the anti-herpes virus compound 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-(2,3-b)quinoxaline.
作者信息
Harmenberg J, Akesson-Johansson A, Gräslund A, Malmfors T, Bergman J, Wahren B, Akerfeldt S, Lundblad L, Cox S
机构信息
Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
出版信息
Antiviral Res. 1991 Mar-Apr;15(3):193-204. doi: 10.1016/0166-3542(91)90066-z.
The compound 2,3-dimethyl-6(2-dimethylaminoethyl)6H-indolo-(2,3-b)quinoxaline (B-220) has been shown to exhibit potent antiviral activity against herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV) and cytomegalovirus (CMV). The mechanism of antiviral action of B-220 against HSV-1 has been studied; from the results it appears that B-220 binds by intercalation into the DNA helix and then disturbs steps that are vital for viral uncoating.
化合物2,3 - 二甲基 - 6(2 - 二甲基氨基乙基) - 6H - 吲哚并(2,3 - b)喹喔啉（B - 220）已被证明对1型单纯疱疹病毒（HSV - 1）、水痘 - 带状疱疹病毒（VZV）和巨细胞病毒（CMV）具有强大的抗病毒活性。已对B - 220抗HSV - 1的抗病毒作用机制进行了研究；结果表明，B - 220通过嵌入DNA螺旋结合，然后干扰对病毒脱壳至关重要的步骤。
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