Thampi B S, Manoj G, Leelamma S, Menon V P
Department of Biochemistry, University of Kerala Trivandrum, India.
Indian J Exp Biol. 1991 Jun;29(6):563-7.
Effect of feeding coconut and blackgram fiber isolated as neutral detergent fiber (NDF) on the levels of lipids and lipid peroxides was studied in rats given a high fat diet. Concentration of cholesterol, free falty acid and phospholipids showed significant decrease in the serum, liver aorta and intestine of coconut and blackgram fiber groups. Concentration of malondialdehyde (MDA) and conjugated dienes was significantly decreased in liver and intestine of both fiber groups, while hydroperoxides showed significant increase in liver and heart of both the fiber groups. SOD and catalase activity was found to be increased in liver, intestine, heart proximal colon and distal colon of both the fiber groups. Serum ceruloplasmin levels showed a slight increase in animals fed coconut and blackgram fiber groups. Glutathione levels in liver, intestine proximal colon, distal colon and heart also showed a significant decrease in the animals of both the fiber groups.
在给予高脂饮食的大鼠中，研究了以中性洗涤纤维（NDF）形式分离出的椰子纤维和黑豆纤维对脂质及脂质过氧化物水平的影响。椰子纤维组和黑豆纤维组大鼠的血清、肝脏、主动脉和肠道中，胆固醇、游离脂肪酸和磷脂的浓度均显著降低。两个纤维组的肝脏和肠道中丙二醛（MDA）和共轭二烯的浓度均显著降低，而两个纤维组的肝脏和心脏中氢过氧化物显著增加。两个纤维组的肝脏、肠道、心脏、近端结肠和远端结肠中，超氧化物歧化酶（SOD）和过氧化氢酶活性均升高。喂食椰子纤维组和黑豆纤维组动物的血清铜蓝蛋白水平略有升高。两个纤维组动物的肝脏、肠道近端结肠、远端结肠和心脏中的谷胱甘肽水平也显著降低。
