Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutrition and Endocrine Research center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Eur J Clin Nutr. 2018 Jan;72(1):174-176. doi: 10.1038/ejcn.2017.113. Epub 2017 Jul 19.
The objective of this study was to investigate whether a diet rich in legumes are associated with oxidative stress among type 2 diabetic patients. In a randomized, controlled, crossover clinical trial, 31 type 2 diabetic patients were randomly assigned to receive 2 diets, each for a period of 8 weeks: (1) The legume-free therapeutic lifestyle change (TLC) diet and (2) the legume-based TLC diet. Both diets were similar except that 2 servings of red meat were replaced by different types of legumes 3 days per week in the legume-based TLC diet. Oxidative stress biomarkers were measured at baseline and after 8 weeks. Compared to the legume-free TLC diet, the legume-based TLC diet significantly decreased malondialdehyde (-0.22 versus -0.68 μmol/l; P=0.002), oxidized-LDL (-0.9 versus -2.3 mU/l; P=0.05) and increased nitric oxide (0.40 versus 0.96 mM/l; P=0.03) and catalase activity (1.2 versus 2.1 Iu/ml; P=0.05).
本研究旨在探讨富含豆类的饮食是否与 2 型糖尿病患者的氧化应激有关。在一项随机、对照、交叉临床试验中，31 例 2 型糖尿病患者被随机分为两组，分别接受为期 8 周的两种饮食：（1）无豆的治疗性生活方式改变（TLC）饮食和（2）基于豆类的 TLC 饮食。两种饮食除了在基于豆类的 TLC 饮食中每周 3 天用不同类型的豆类代替 2 份红肉外，其他方面均相似。在基线和 8 周后测量氧化应激生物标志物。与无豆的 TLC 饮食相比，基于豆类的 TLC 饮食显著降低了丙二醛（-0.22 对-0.68 μmol/L；P=0.002）、氧化型 LDL（-0.9 对-2.3 mU/L；P=0.05），增加了一氧化氮（0.40 对 0.96 mM/L；P=0.03）和过氧化氢酶活性（1.2 对 2.1 Iu/ml；P=0.05）。
