Chu Yueng-Hsiang, Wu Chin-Chen, Kao Chuan-Hsiang, Wang Hsing-Won
Graduate Institute of Medical Sciences, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Am J Rhinol. 2006 Jan-Feb;20(1):84-6.
The purpose of this study was to evaluate the effect of low temperature on basal tension in isolated hypertrophic human nasal mucosa with or without alpha1-agonist stimulation.
A tissue bath for isolated nasal mucosa was used. Tension in strips of human turbinate mucosa that were untreated and treated with an alpha1-adrenoreceptor agonist, methoxamine (10 microM), was recorded continuously in a stepwise manner in temperatures that varied from 37 to 10 degrees C.
The changes of tension in the human nasal mucosa were found to be temperature-dependent in both untreated and treated tissues, with tension decreasing to 48.6% at 10 degrees C in comparison with 100% at 37 degrees C in the untreated group, the presence of methoxamine (10 microM) had minimal effect.
Low temperature induced a rapid and reproducible relaxation in isolated hypertrophic human nasal mucosa that was not affected by the presence of the alpha1-agonist methoxamine (10 microM).
本研究旨在评估低温对有或无α1激动剂刺激的离体肥厚性人鼻黏膜基础张力的影响。
使用用于离体鼻黏膜的组织浴。在37至10摄氏度的不同温度下，以逐步方式连续记录未处理和用α1肾上腺素能受体激动剂甲氧明（10微摩尔）处理的人鼻甲黏膜条的张力。
在未处理和处理的组织中，均发现人鼻黏膜张力的变化与温度有关，未处理组在10摄氏度时张力降至48.6%，而在37摄氏度时为100%，甲氧明（10微摩尔）的存在影响极小。
低温可使离体肥厚性人鼻黏膜快速且可重复地松弛，α1激动剂甲氧明（10微摩尔）的存在对此无影响。
