Zalewski Peter D
Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia.
Curr Opin Pharmacol. 2006 Jun;6(3):237-43. doi: 10.1016/j.coph.2006.01.005. Epub 2006 Mar 15.
Zinc, an essential dietary metal, has special roles in the conducting airways. Under the control of specific zinc transporters, abundant labile zinc localizes to the apical cytoplasm of airway epithelium. Zinc influences a number of important airway proteins, including ADAM33 metalloproteinase, beta2 adrenoreceptors and nuclear factor-kappabeta, and has anti-inflammatory, anti-oxidant and pro-survival actions. Zinc deficiency results in enhanced oxidative damage in the airways by causing infiltration of inflammatory cells and increased superoxide and nitric oxide production. When zinc deficiency occurs in conjunction with acute lung injury or asthma, a more intense inflammation is produced. Zinc is also able to restore chloride secretion in cystic fibrosis models. Research priorities include the development of safe and non-invasive ways to monitor airway zinc levels and to supplement airway zinc when needed.
锌是一种必需的膳食金属，在传导气道中具有特殊作用。在特定锌转运蛋白的控制下，大量不稳定的锌定位于气道上皮细胞的顶端细胞质中。锌会影响多种重要的气道蛋白，包括ADAM33金属蛋白酶、β2肾上腺素能受体和核因子κB，具有抗炎、抗氧化和促生存作用。锌缺乏会导致炎症细胞浸润，增加超氧化物和一氧化氮的产生，从而增强气道中的氧化损伤。当锌缺乏与急性肺损伤或哮喘同时发生时，会产生更强烈的炎症。在囊性纤维化模型中，锌还能够恢复氯化物分泌。研究重点包括开发安全、无创的方法来监测气道锌水平，并在需要时补充气道锌。
