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伴刀豆球蛋白A诱导小鼠T淋巴细胞钙摄取增加及其受环核苷酸的调节

Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides.

作者信息

Freedman M H, Raff M C

出版信息

Nature. 1975 May 29;255(5507):378-82. doi: 10.1038/255378a0.

DOI:10.1038/255378a0
PMID:165431
Abstract

The binding of concanavqlin A to T but not B mouse spleen lymphocytes increases Ca-2+ uptake in these cells which is measurable by 45 s and complete by 1 min. Dibutyrl cyclic AMP, but not sodium azide inhibits induced Ca-2+ uptake, wheras dibutyryl cyclic GMP enhances it. B cell mitogens do not cause a similar Ca-2+ uptake in mouse B lymphocytes. The induction of increased Ca-2+ uptake by T cells is discussed in terms of gated membrane channels for Ca-2+.

摘要

伴刀豆球蛋白A与小鼠T淋巴细胞而非B淋巴细胞的结合增加了这些细胞对Ca²⁺的摄取，45秒时可检测到这种摄取，1分钟时摄取完成。二丁酰环磷酸腺苷而非叠氮化钠抑制诱导的Ca²⁺摄取，而二丁酰环磷酸鸟苷则增强这种摄取。B细胞促有丝分裂原不会在小鼠B淋巴细胞中引起类似的Ca²⁺摄取。从Ca²⁺的门控膜通道角度讨论了T细胞诱导Ca²⁺摄取增加的情况。

相似文献

1
Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides.伴刀豆球蛋白A诱导小鼠T淋巴细胞钙摄取增加及其受环核苷酸的调节
Nature. 1975 May 29;255(5507):378-82. doi: 10.1038/255378a0.
2
Modification of the lymphocyte response to mitogens by cyclic AMP and GMP.环磷酸腺苷和环磷酸鸟苷对淋巴细胞有丝分裂原反应的调节作用。
J Reticuloendothel Soc. 1974 Nov;16(5):289-99.
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Activation of murine lymphocytes by cyclic guanosine 3',5'-monophosphate: specificity and role in mitogen activity.环磷酸鸟苷对小鼠淋巴细胞的激活作用：特异性及其在有丝分裂原活性中的作用。
Biochim Biophys Acta. 1976 Mar 25;428(1):91-103. doi: 10.1016/0304-4165(76)90111-2.
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Specific mitogenic activity of 8-Br-guanosine 3',5'-monophosphate (Br-cyclic GMP) on B lymphocytes.8-溴鸟苷3',5'-单磷酸（Br-环鸟苷酸）对B淋巴细胞的特异性促有丝分裂活性。
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The antagonistic action of cyclic GMP and cyclic AMP on proliferation of B and T lymphocytes.环磷酸鸟苷和环磷酸腺苷对B淋巴细胞和T淋巴细胞增殖的拮抗作用。
Immunology. 1975 Jan;28(1):113-9.
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Correlation between mitogenicity and stimulation of calcium uptake in human lymphocytes.人淋巴细胞中促有丝分裂活性与钙摄取刺激之间的相关性。
Biochem Biophys Res Commun. 1974 Dec 23;61(4):1180-6. doi: 10.1016/s0006-291x(74)80408-0.
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The effect of cyclic nucleotides on purine biosynthesis and the induction of PRPP synthetase during lymphocyte activation.环核苷酸对淋巴细胞活化过程中嘌呤生物合成及磷酸核糖焦磷酸合成酶诱导的影响。
Cell. 1974 Dec;3(4):375-80. doi: 10.1016/0092-8674(74)90053-1.
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The influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis.环核苷酸细胞内水平对细胞增殖及抗体合成诱导的影响。
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The involvement of cyclic nucleotide metabolism in the initiation of lymphocyte proliferation induced by mitogens.环核苷酸代谢在有丝分裂原诱导的淋巴细胞增殖起始过程中的作用。
J Immunol. 1976 Nov;117(5 Pt 1):1656-63.
10
Cyclic AMP and the immune response;环磷酸腺苷与免疫反应；
Adv Cyclic Nucleotide Res. 1974;4(0):1-79.

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J Membr Biol. 1994 Jan;137(2):159-68. doi: 10.1007/BF00233485.
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