环磷酸鸟苷和环磷酸腺苷对B淋巴细胞和T淋巴细胞增殖的拮抗作用。
The antagonistic action of cyclic GMP and cyclic AMP on proliferation of B and T lymphocytes.
作者信息
Diamantstein T, Ulmer A
出版信息
Immunology. 1975 Jan;28(1):113-9.
Abstract
The effect of c-AMP, c-GMP and both substances together on (3H)-thymidine incorporation into nuclear DNA was investigated using spleen cells of normal and athymic nude mice. c-GMP induces DNA synthesis in both normal and nude spleen cell populations. c-AMP inhibited the stimulatory activity of c-GMP as well as the phytohaemagglutinin (PHA) and lipopolysaccharide (LPS) response of spleen cells. The inhibitory activity of c-AMP on the PHA and LPS responses can be reversed by c-GMP. The possible role of cyclic nucleotides in the regulation of cell proliferation and of the immune response is discussed.
摘要
利用正常小鼠和无胸腺裸鼠的脾细胞，研究了环磷酸腺苷（c-AMP）、环磷酸鸟苷（c-GMP）以及二者共同作用对（3H）-胸腺嘧啶核苷掺入细胞核DNA的影响。c-GMP可诱导正常和裸鼠脾细胞群体中的DNA合成。c-AMP抑制c-GMP的刺激活性以及脾细胞对植物血凝素（PHA）和脂多糖（LPS）的反应。c-GMP可逆转c-AMP对PHA和LPS反应的抑制活性。文中讨论了环核苷酸在细胞增殖调节和免疫反应中的可能作用。
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