Saraiva Luciana, Lotufo Roberto F M, Pustiglioni Alessandro N, Silva Helio T, Imbronito Ana Vitoria
Department of Periodontology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Apr;101(4):457-62. doi: 10.1016/j.tripleo.2005.08.004. Epub 2006 Jan 4.
The purpose of this study was to identify the presence of periodontal microrganisms in 35 renal transplant patients before the transplant procedure.
At each time point, clinical parameters were recorded and subgingival plaque samples were collected from 4 different sites at days 30 and 90 after surgery. Samples were plated onto selective and nonselective media to determine total colony counts and the presence of putative periodontal pathogens. After transplant surgery, patients received immunosuppressive therapy.
Statistical analysis of the microbiologic data showed significant changes between time points. An increase in total counts of microrganisms was observed on day 90 after surgery. As a side effect of cyclosporine, 14 patients developed gingival overgrowth. Beta-hemolytic Streptococcus was more frequently detected in patients who did not present gingival overgrowth 90 days after surgery.
Quantitative and qualitative changes of the subgingival microflora can occur 90 days after transplant surgery, while patients are still under immunosupressive drugs.
本研究的目的是确定35例肾移植患者在移植手术前牙周微生物的存在情况。
在每个时间点，记录临床参数，并在术后第30天和第90天从4个不同部位采集龈下菌斑样本。将样本接种在选择性和非选择性培养基上，以确定总菌落数和假定的牙周病原体的存在情况。移植手术后，患者接受免疫抑制治疗。
微生物学数据的统计分析显示各时间点之间有显著变化。术后第90天观察到微生物总数增加。作为环孢素的副作用，14例患者出现牙龈增生。术后90天未出现牙龈增生的患者中更频繁地检测到β-溶血性链球菌。
移植手术后90天，患者仍在使用免疫抑制药物时，龈下微生物群可发生定量和定性变化。
