人类蛋白质图谱描绘了一个多样化的领域。

Human Protein Atlas charts a diverse terrain.

作者信息

Saviranta Petri, Kallioniemi Olli

机构信息

Medical Biotechnology, VTT Technical Research Centre of Finland and University of Turku, Itäinen Pitkäkatu 4A, FIN-20520 Turku, Finland.

出版信息

Trends Biotechnol. 2006 May;24(5):195-7. doi: 10.1016/j.tibtech.2006.03.002. Epub 2006 Mar 20.

DOI:10.1016/j.tibtech.2006.03.002

PMID:16545876

Abstract

A complete set of high-quality antibodies against the human proteome would constitute a remarkable resource for the analysis of protein abundances in tissues, facilitating systematic protein expression profiling in health and disease. In two recent papers, Swedish researchers describe a concerted effort towards producing a 'Human Protein Atlas' by combining high-throughput antibody generation with immunohistochemical profiling of tissue microarrays.

摘要

一套完整的针对人类蛋白质组的高质量抗体将成为分析组织中蛋白质丰度的宝贵资源，有助于在健康和疾病状态下进行系统的蛋白质表达谱分析。在最近的两篇论文中，瑞典研究人员描述了他们通过将高通量抗体生成与组织微阵列的免疫组织化学分析相结合，为制作“人类蛋白质图谱”而做出的协同努力。