酶免疫法抗EBV/IgG检测小儿患者EB病毒免疫状态的敏感性。
Sensitivity of the Enzygnost anti-EBV/IgG for the determination of the Epstein-Barr virus immune status in pediatric patients.
作者信息
Kleines Michael, Scheithauer Simone, Ritter Klaus, Häusler Martin
机构信息
Division of Virology, Department of Medical Microbiology, UK Aachen, RWTH Aachen, 52074 Aachen, Germany.
出版信息
Diagn Microbiol Infect Dis. 2006 Jul;55(3):247-9. doi: 10.1016/j.diagmicrobio.2006.01.011. Epub 2006 Mar 20.
The Enzygnost Anti-EBV/IgG shows good performance for populations not defined by age. Samples from 349 pediatric outpatients were screened with the assay and with immunofluorescence assay (IFA) as the gold standard. The Enzygnost assay showed a sensitivity of 85%. Ten and one-tenth percent of EBV seropositive samples were classified as intermediate, and 4.9% were falsely determined as seronegative when compared to the standard IgG anti-virus capsid antigen (VCA) IFA. Our data suggest a limited sensitivity of the assay with samples from pediatric patients.
恩济诺斯抗EBV/IgG检测试剂在未按年龄界定的人群中表现良好。采用该检测试剂对349名儿科门诊患者的样本进行筛查，并以免疫荧光检测法（IFA）作为金标准。恩济诺斯检测试剂的灵敏度为85%。与标准的IgG抗病毒衣壳抗原（VCA）IFA相比，10.1%的EBV血清阳性样本被归类为中间型，4.9%的样本被错误判定为血清阴性。我们的数据表明，该检测试剂对儿科患者样本的灵敏度有限。
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