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Negative regulation of CD45 protein tyrosine phosphatase activity by ionomycin in T cells.

作者信息

Ostergaard H L, Trowbridge I S

机构信息

Department of Cancer Biology, Salk Institute, San Diego, CA 92186.

出版信息

Science. 1991 Sep 20;253(5026):1423-5. doi: 10.1126/science.1654595.

DOI:10.1126/science.1654595
PMID:1654595
Abstract

CD45 is a leukocyte-specific, transmembrane protein tyrosine phosphatase (PTPase) required for T cell responsiveness. How the activity of PTPases is regulated in vivo is unclear. Treatment of murine thymocytes and a variety of murine T cell lines with the calcium ionophore ionomycin decreased CD45 PTPase activity. Ionomycin treatment also led to a decreased phosphorylation of serine residues in CD45. These results indicate that increased intracellular calcium modulates CD45 PTPase activity, demonstrating regulation of CD45 PTPase activity in vivo, and also implicate serine dephosphorylation as a possible mechanism.

摘要

相似文献

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Negative regulation of CD45 protein tyrosine phosphatase activity by ionomycin in T cells.
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2
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Novel redistribution of an intracellular pool of CD45 accompanies T cell activation.CD45细胞内池的新型重新分布伴随T细胞活化。
J Biol Chem. 1991 May 15;266(14):9222-30.

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