细胞色素氧化酶与氧气反应中的功能中间体。
Functional intermediates in reaction of cytochrome oxidase with oxygen.
作者信息
Chance B, Saronio C, Leigh J S
出版信息
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1635-40. doi: 10.1073/pnas.72.4.1635.
Abstract
The development of a low temperature kinetic method for the flash photolysis of the compounds of membrane-bound cytochrome a3 with carbon monoxide in the presence of oxygen affords evidence for three categories of functional intermediate compounds of cytochrome a3 and oxygen. The three classes are identified as follows: Compounds of Type A are considered to be "oxy" compounds of the ferrous heme. They have the composition a3-2+. O2. Compounds of Type B are considered to be peroxide compounds (CU-2+A3-3+ O-2= or CU-2+A3-3+ O2H2) or the equivalent heme Fe-Cu peroxide bridge structures. Compounds of Type C are formed from the ferricyanide pretreated oxidase and may involve higher oxidation states of the heme iron such as quadrivalent iron, and peroxide. Kinetic and equilibrium studies show these compounds to be functional in oxygen reduction in the sequence A yields B yield cytochromes a, c, c1, etc.
摘要
开发了一种低温动力学方法，用于在有氧存在的情况下对膜结合细胞色素a3与一氧化碳的化合物进行闪光光解，这为细胞色素a3和氧的三类功能性中间化合物提供了证据。这三类化合物的鉴定如下：A类化合物被认为是亚铁血红素的“氧合”化合物。它们的组成为a3-2 +.O2。B类化合物被认为是过氧化物化合物（CU-2 + A3-3 + O-2 =或CU-2 + A3-3 + O2H2）或等效的血红素铁 - 铜过氧化物桥结构。C类化合物由经铁氰化物预处理的氧化酶形成，可能涉及血红素铁的更高氧化态，如四价铁和过氧化物。动力学和平衡研究表明，这些化合物在氧还原过程中按A产生B产生细胞色素a、c、c1等的顺序发挥作用。
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