Yu M W, You S L, Chang A S, Lu S N, Liaw Y F, Chen C J
Institute of Public Health, National Taiwan University College of Medicine, Taipei.
Cancer Res. 1991 Oct 15;51(20):5621-5.
In order to assess the association between antibodies to hepatitis C virus (anti-HCV) and hepatocellular carcinoma (HCC), as well as the interaction of anti-HCV with other HCC risk factors in Taiwan, a total of 127 pairs of newly diagnosed HCC patients and healthy community controls were studied. Case-control pairs were individually matched for age (+/- 3 years), sex, residence, and ethnicity. Serum samples from study subjects were examined for anti-HCV by enzyme immunoassays as well as hepatitis B surface antigen (HBsAg) and e antigen (HBeAg) by radioimmunoassays using commercial kits. The habits of cigarette smoking, alcohol drinking, and peanut consumption were obtained through standardized interviews according to a structured questionnaire. Both the anti-HCV as well as the carrier status of HBsAg and HBeAg were significantly associated with HCC showing a multivariate-adjusted odds ratio of 24.8 for carriers of HBsAg alone, 33.5 for carriers of both HBsAg and HBeAg, and 23.7 for those who were positive for anti-HCV. The population-attributable risk percentage was estimated as 3% for anti-HCV alone, 69% for HBsAg carrier status alone, and 6% for both anti-HCV and HBsAg in Taiwan. There were also synergistic effects on HCC development for anti-HCV with HBsAg carrier status, cigarette smoking, and habitual alcohol drinking.
为了评估台湾地区丙型肝炎病毒抗体（抗-HCV）与肝细胞癌（HCC）之间的关联，以及抗-HCV与其他HCC危险因素的相互作用，共研究了127对新诊断的HCC患者和健康社区对照。病例对照配对在年龄（±3岁）、性别、居住地和种族方面进行了个体匹配。使用商业试剂盒通过酶免疫测定法检测研究对象的血清样本中的抗-HCV，通过放射免疫测定法检测乙肝表面抗原（HBsAg）和e抗原（HBeAg）。吸烟、饮酒和食用花生的习惯通过根据结构化问卷进行的标准化访谈获得。抗-HCV以及HBsAg和HBeAg的携带状态均与HCC显著相关，单独HBsAg携带者的多变量调整比值比为24.8，HBsAg和HBeAg携带者为33.5，抗-HCV阳性者为23.7。在台湾，单独抗-HCV的人群归因风险百分比估计为3%，单独HBsAg携带状态为69%，抗-HCV和HBsAg两者为6%。抗-HCV与HBsAg携带状态、吸烟和习惯性饮酒对HCC发生也有协同作用。
