Kelleher J J, Varani J
Antimicrob Agents Chemother. 1976 Aug;10(2):229-33. doi: 10.1128/AAC.10.2.229.
The photoinactivation of actively and nonactively growing herpes simplex virus by neutral red and proflavine was studied in rabbit kidney cells. Active virus growth was inhibited by both dyes under conditions which did not destroy the cells. Neutral red caused a much greater inhibition than proflavine. Neutral red also caused a reduction in the reactivation rate of latent virus when the infected cells were treated during the latent period. In the treated cultures that did reactivate virus, the average length of the latent period was increased over the control value. Proflavine treatment did not reduce the rate of reactivation of latent virus and did not increase the average latent period of the treated cultures.
在兔肾细胞中研究了中性红和硫酸原黄素对活跃生长和非活跃生长的单纯疱疹病毒的光灭活作用。在不破坏细胞的条件下，两种染料均抑制病毒的活跃生长。中性红的抑制作用比硫酸原黄素大得多。当在潜伏期对感染细胞进行处理时，中性红还会降低潜伏病毒的复活率。在确实重新激活病毒的处理培养物中，潜伏期的平均长度比对照值增加。硫酸原黄素处理不会降低潜伏病毒的复活率，也不会增加处理培养物的平均潜伏期。
