Kemper O, Derré J, Cherif D, Engelmann H, Wallach D, Berger R
Department of Molecular Genetics and Virology, Weitzmann Institute of Science, Rehovot, Israel.
Hum Genet. 1991 Sep;87(5):623-4. doi: 10.1007/BF00209026.
The gene encoding the type II (p75) tumor necrosis factor receptor (TNF-RII) has been localized on human chromosome 1, band 1p36.2 by nonradioactive in situ hybridization. The gene encoding the type I (p55) TNF-R, which is structurally homologous to the type II (p75) TNF-R, has been previously localized on chromosome 12 band 12p13. Thus, despite their probable common ancestry, the genes for the two TNF-Rs are localized on different chromosomes.
编码II型(p75)肿瘤坏死因子受体(TNF-RII)的基因已通过非放射性原位杂交定位到人类染色体1的1p36.2带。编码I型(p55)TNF-R的基因,其在结构上与II型(p75)TNF-R同源,先前已定位到染色体12的12p13带。因此,尽管这两种TNF-Rs可能有共同的起源,但它们的基因却定位在不同的染色体上。