两例伴有变异易位的急性早幼粒细胞白血病：17号染色体异常的重要性
Two cases of acute promyelocytic leukemia with variant translocations: the importance of chromosome No. 17 abnormality.
作者信息
Yamada K, Sugimoto E, Amano M, Imamura Y, Kubota T, Matsumoto M
出版信息
Cancer Genet Cytogenet. 1983 Jun;9(2):93-9. doi: 10.1016/0165-4608(83)90029-8.
Two patients with acute promyelocytic leukemia (APL) were found to have chromosomal translocations in their leukemic cells; one had a 46,XX,t(7;17)(q36;q22) and another a 46,XY,t(1;17)(p36;q21) karyotype. These two cases of APL seem to be the first involving variant translocations instead of the standard t(15q+; 17q-) translocation. The present cases strongly suggest that the rearrangement of chromosome #17, which occurs in bands of the q21-22 region of the long arm, is crucially important in the pathogenesis of APL.
两名急性早幼粒细胞白血病（APL）患者的白血病细胞中发现了染色体易位；一名患者的核型为46,XX,t(7;17)(q36;q22)，另一名患者的核型为46,XY,t(1;17)(p36;q21)。这两例APL似乎是首例涉及变异易位而非标准t(15q+; 17q-)易位的病例。目前的病例有力地表明，发生在17号染色体长臂q21 - 22区域条带的重排在APL发病机制中至关重要。
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