Havill L M, Hale L G, Newman D E, Witte S M, Mahaney M C
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
J Med Primatol. 2006 Apr;35(2):97-105. doi: 10.1111/j.1600-0684.2006.00150.x.
Serum bone-specific alkaline phosphatase (bone ALP) and intact osteocalcin (OC) are markers of bone formation of interest because of easy measurability and potential utility as identifiers of those at risk for fractures associated with bone metabolism disorders. The baboon (Papio hamadryas) exhibits extensive biological similarities to humans making it particularly well suited to studies of bone maintenance and turnover.
We measured serum bone ALP and OC in 591 baboons.
We report significant sex and age effects and present reference ranges and percentile distributions for these markers.
This study is the first to characterize normal variation in bone ALP and OC levels in baboons and to assess the age and sex effects on this variation. The results provide much-needed reference standards to allow researchers to evaluate the status of their animals in cross-sectional studies and assess the meaning of changes in bone ALP and OC levels in longitudinal studies.
血清骨特异性碱性磷酸酶（骨碱性磷酸酶）和完整骨钙素是备受关注的骨形成标志物，因为它们易于测量，并且有可能作为识别与骨代谢紊乱相关骨折风险人群的指标。狒狒（阿拉伯狒狒）与人类具有广泛的生物学相似性，这使其特别适合用于骨维持和骨转换的研究。
我们测量了591只狒狒的血清骨碱性磷酸酶和骨钙素。
我们报告了显著的性别和年龄效应，并给出了这些标志物的参考范围和百分位数分布。
本研究首次描述了狒狒骨碱性磷酸酶和骨钙素水平的正常变异，并评估了年龄和性别对这种变异的影响。研究结果提供了急需的参考标准，使研究人员能够在横断面研究中评估其动物的状态，并在纵向研究中评估骨碱性磷酸酶和骨钙素水平变化的意义。
