D-环丝氨酸抑制结核分枝杆菌蜡质 D 肽聚糖脂质的合成。
Inhibition of the Synthesis of Wax D Peptidoglycolipid of Mycobacterium tuberculosis by d-Cycloserine.
机构信息
Tuberculosis Research Laboratory, Veterans Administration Hospital, and the Institute for Enzyme Research, University of Wisconsin, Madison, Wisconsin 53705.
出版信息
Infect Immun. 1970 Jan;1(1):74-7. doi: 10.1128/iai.1.1.74-77.1970.
Abstract
The antibiotic d-cycloserine inhibits the synthesis of the wax D peptidoglycolipid in cells of the H37Ra strain of Mycobacterium tuberculosis. This inhibition occurs at a lower concentration of the drug than that required for the inhibition of growth. The inhibition is completely reversed by d-alanine. An arabino-galactan-galactosamine-(diaminopimelic acid)-mycolate accumulates in H37Ra cells exposed to the antibiotic. The chemical and functional group analyses of this lipid suggests it to be a possible precursor to the synthesis of wax D.
摘要
抗生素 D-环丝氨酸抑制分枝杆菌 H37Ra 菌株细胞中蜡 D 肽聚糖脂质的合成。这种抑制作用发生在比抑制生长所需的药物浓度更低的情况下。这种抑制作用可以被 D-丙氨酸完全逆转。在暴露于抗生素的 H37Ra 细胞中积累了阿拉伯半乳糖甘露聚糖-半乳糖胺-(二氨基庚二酸)-枝酸酯。这种脂质的化学和官能团分析表明，它可能是蜡 D 合成的前体。
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