免疫血清未能显著增强金黄色葡萄球菌的吞噬作用：吞噬作用促进因子的非特异性吸附。
Failure of Immune Sera to Enhance Significantly Phagocytosis of Staphylococus aureus: Nonspecific Adsorption of Phagocytosis-Promoting Factors.
机构信息
Department of Community Medicine, School of Medicine, University of Pennsylvania.
出版信息
Infect Immun. 1970 Dec;2(6):742-9. doi: 10.1128/iai.2.6.742-749.1970.
Serum from rabbits immunized with either heat-killed or live nonencapsulated Staphylococcus aureus failed further to enhance phagocytosis and intracellular killing of the homologous organism by either normal rabbit polymorphonuclear leukocytes or monocytes, when compared with normal rabbit serum. These immune sera did, however, show an increase in agglutinating and precipitating antibody level. Adsorption of normal human serum with some gram-positive and gram-negative bacteria, yeast, and some inert particles significantly reduced the phagocytosis-promoting factors of the serum. It would seem, then, that nonencapsulated S. aureus differs from other pathogenic bacteria in that the humoral antibacterial factors promoting its phagocytosis and intracellular killing are not significantly enhanced by infection or immunization.
用加热杀死或活的非荚膜金黄色葡萄球菌免疫的兔子的血清与正常兔的多形核白细胞或单核细胞比较，不能进一步增强对同源菌的吞噬和细胞内杀伤作用，而正常兔血清则有这种增强作用。这些免疫血清的凝集和沉淀抗体水平确实增高。用一些革兰阳性和革兰阴性细菌、酵母和一些惰性颗粒吸附正常人血清，可显著减少血清中的吞噬作用促进因子。因此，非荚膜金黄色葡萄球菌不同于其他病原菌，因为体液抗菌因子不能显著地因感染或免疫而增强对它的吞噬和细胞内杀伤作用。
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