Lenhart N, Mudd S
Infect Immun. 1972 May;5(5):763-8. doi: 10.1128/iai.5.5.763-768.1972.
The capability of macrophages to inactivate ingested staphylococci can be augmented when repeated infection is followed by specific elicitation with staphylococcal lysate. The increase in staphylococcidal capability with specific elicitation after infection is not dramatic but is statistically significant. The percentage of change in staphylococcidal capability after infection and specific elicitation is systematically related to the staphylococcidal capability of the populations of macrophages in the same rabbits studied prior to infection. When the capability of the initial populations of macrophages has been high, the percentage of change after infection and elicitation may be slight or even negative. When the staphylococcidal capability of the initial population of macrophages in a given rabbit has been low, there is typically a significant increase in this capability after infection and elicitation. It is shown at the cellular level that it is possible to evoke a population of activated macrophages, by a procedure which is analogous to procedures reported as useful in human practice.
当反复感染后用葡萄球菌裂解物进行特异性激发时，巨噬细胞使摄入的葡萄球菌失活的能力会增强。感染后经特异性激发，杀葡萄球菌能力的增加并不显著，但具有统计学意义。感染和特异性激发后杀葡萄球菌能力的变化百分比与同一兔子感染前研究的巨噬细胞群体的杀葡萄球菌能力存在系统性关联。当初始巨噬细胞群体的能力较高时，感染和激发后的变化百分比可能很小甚至为负。当给定兔子的初始巨噬细胞群体的杀葡萄球菌能力较低时，感染和激发后这种能力通常会显著增加。在细胞水平上表明，通过一种类似于在人类实践中报道的有用方法的程序，可以诱导出一群活化的巨噬细胞。
