Departments of Microbiology and Anatomy, New York State Veterinary College, Cornell University, Ithaca, New York 14850.
Infect Immun. 1971 Jun;3(6):833-7. doi: 10.1128/iai.3.6.833-837.1971.
Inoculation of susceptible newborn kittens with a large dose of panleukopenia virus caused subclinical infection in 19 of 23 cases. All infected kittens developed severe and prolonged leukopenia. Cell-free virus was present in the blood from 1 to 7 postinoculation days. The virus spread to all organs, regardless of the route of inoculation. The thymus, spleen, mesenteric lymph nodes, and the cerebellum were the most severely infected organs. Kittens responded to virus infection by production of specific antibodies, first detectable in the circulatory system 6 to 8 days after infection. Antibody production preceded recovery from leukopenia by 3 days.
给易感染的新生小猫接种大剂量的泛白细胞减少症病毒，导致 23 例中有 19 例出现亚临床感染。所有受感染的小猫均出现严重且持续的白细胞减少症。感染后 1 至 7 天，血液中存在无细胞病毒。病毒传播到所有器官，无论接种途径如何。感染最严重的器官是胸腺、脾脏、肠系膜淋巴结和小脑。小猫通过产生特异性抗体来应对病毒感染，在感染后 6 至 8 天首次在循环系统中检测到。抗体产生早于白细胞减少症恢复 3 天。
