Zhang J, Xiang G, Xiang L, Sun H
Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan, 430070, Hubei, People's Republic of China,
J Endocrinol Invest. 2014 May;37(5):441-7. doi: 10.1007/s40618-013-0034-9. Epub 2014 Jan 9.
Increased serum uric acid levels and vascular atherosclerosis are very common in diabetes. However, few studies focused on the relationship between serum uric acid and aortic or peripheral arterial stiffness in newly diagnosed diabetic patients. This study investigated the association between serum uric acid levels and carotid-femoral pulse wave velocity (cfPWV) or carotid-radial (cr) PWV in male patients with newly diagnosed type 2 diabetes mellitus (T2DM).
106 male patients with newly diagnosed T2DM were recruited. cfPWV and crPWV as well as anthropometric parameters, blood pressure, serum uric acid, blood glucose, fasting insulin, C-reactive protein and blood lipids were measured.
The subjects were divided into low uric acid (UA) subgroup and high UA subgroup according to uric acid median. cfPWV and crPWV were significantly higher in high UA subgroup. Serum uric acid significantly correlated with cfPWV (r = 0.533, P < 0.001), crPWV (r = 0.334, P = 0.001), waist circumference (r = 0.350, P < 0.001), waist-to-hip ratio (r = 0.254, P = 0.009), fasting insulin (r = 0.432, P < 0.001), HOMA-IR (r = 0.173, P = 0.042), fasting blood glucose (r = -0.271, P = 0.005), haemoglobin A1c (r = -0.202, P = 0.038), and HDL-cholesterol (r = -0.267, P = 0.006) after correction for age. Stepwise multiple regressions showed that the independent determinants of cfPWV were serum uric acid, age, C-reactive protein, HDL-cholesterol, and smoking status. And the independent determinants of crPWV were serum uric acid, age, diastolic blood pressure, and HDL-cholesterol.
Serum uric acid is significantly associated with increased aortic and peripheral arterial stiffness in men with T2DM at the early stage.
血清尿酸水平升高与血管动脉粥样硬化在糖尿病患者中非常常见。然而，很少有研究关注新诊断糖尿病患者血清尿酸与主动脉或外周动脉僵硬度之间的关系。本研究调查了新诊断的2型糖尿病（T2DM）男性患者血清尿酸水平与颈股脉搏波速度（cfPWV）或颈桡脉搏波速度（crPWV）之间的关联。
招募106例新诊断的T2DM男性患者。测量cfPWV和crPWV以及人体测量参数、血压、血清尿酸、血糖、空腹胰岛素、C反应蛋白和血脂。
根据尿酸中位数将受试者分为低尿酸（UA）亚组和高尿酸亚组。高尿酸亚组的cfPWV和crPWV显著更高。校正年龄后，血清尿酸与cfPWV（r = 0.533，P < 0.001）、crPWV（r = 0.334，P = 0.001）、腰围（r = 0.350，P < 0.001）、腰臀比（r = 0.254，P = 0.009）、空腹胰岛素（r = 0.432，P < 0.001）、HOMA-IR（r = 0.173，P = 0.042）、空腹血糖（r = -0.271，P = 0.005）、糖化血红蛋白（r = -0.202，P = 0.038）和高密度脂蛋白胆固醇（r = -0.267，P = 0.006）显著相关。逐步多元回归显示，cfPWV的独立决定因素是血清尿酸、年龄、C反应蛋白、高密度脂蛋白胆固醇和吸烟状态。crPWV的独立决定因素是血清尿酸、年龄、舒张压和高密度脂蛋白胆固醇。
血清尿酸与T2DM男性早期主动脉和外周动脉僵硬度增加显著相关。
