Terpstra C, Wensvoort G
Centraal Diergeneeskundig Instituut, afdeling Virologie, Lelystad.
Tijdschr Diergeneeskd. 1991 Oct 1;116(19):943-8.
Since 1976 nineteen naturally occurring and eight experimentally induced incidents of congenital bovine viral diarrhoea virus (BVDV) infections were detected in routine laboratory diagnosis of swine fever. In nearly all naturally occurring cases, the disease was limited to one litter only. Clinical signs of disease and gross pathological lesions resembled those of chronic swine fever. Nearly all piglets born infected with the disease died within four months of birth. One pig remained persistently infected and immunotolerant until slaughtered at the age of 24 months; one of its litter mates seroconverted when six months old. In contrast, postnatal infections of pigs with BVDV strains isolated from swine ran a nearly or completely subclinical course. A serological survey of slaughter sows and boars showed that 20 per cent of the animals had antibodies against BVDV. The percentage of seropositive pigs was significantly higher on farms where cattle were present, and the percentage increased with age regardless of whether cattle were present. Sheep, pigs and humans can also transmit BVDV infections to pigs.
自1976年以来,在猪瘟的常规实验室诊断中检测到19起自然发生的和8起实验诱导的先天性牛病毒性腹泻病毒(BVDV)感染事件。在几乎所有自然发生的病例中,疾病仅局限于一窝仔猪。疾病的临床症状和大体病理病变与慢性猪瘟相似。几乎所有感染该疾病出生的仔猪在出生后四个月内死亡。一头猪持续感染并具有免疫耐受性,直到24月龄时被屠宰;它的一窝仔猪中有一头在6月龄时血清学发生了转换。相比之下,用从猪分离的BVDV毒株对猪进行产后感染,其病程几乎或完全呈亚临床经过。对屠宰母猪和公猪的血清学调查表明,20%的动物具有抗BVDV抗体。在有牛的农场中,血清阳性猪的百分比显著更高,且无论是否有牛,血清阳性猪的百分比都随年龄增加。绵羊、猪和人类也可将BVDV感染传播给猪。