Department of Biochemistry, J. N. Medical College, Belgaum, Karnataka, India.
Eur Rev Med Pharmacol Sci. 2010 Nov;14(11):959-67.
Rheumatoid arthritis (RA) is a chronic multisystem disease of unknown cause. Formation of reactive oxygen species and lipid peroxides as a result of disease activity may play an important role. Oxidative stress and decreased antioxidant status are the hallmarks in patients of RA as observed in recent years. The objectives of the study was to determine oxidative stress by measuring malondialdehyde and enzymatic antioxidant status by estimating superoxide dismutase and glutathione reductase in patients of RA and then comparing with healthy individuals.
The present study comprises of 40 RA cases who were clinically diagnosed and confirmed by laboratory tests, attending KLE Society's Dr. Prabhakar Kore Hospital and Research Centre, Belgaum. Southern India attached to J. N. Medical College. between September 2007 to August 2008. All the patients were in the age group of 40-60 years including both the sexes. Biochemical parameters like malondialdehyde, enzymatic antioxidants like superoxide dismutase and glutathione reductase were estimated in cases (40) and controls (40).
The mean level of blood malondialdehyde (in nmol/ml) in controls was 6.19 +/- 0.96 and 11.48 +/- 0.76 in cases. The mean level of superoxide dismutase (IU/g of Hb) in controls was 948.32 +/- 99.88 and 443.68 +/- 111.69 in the cases. The mean glutathione reductase level (in IU/g of Hb) in controls was 8.91 +/- 1.04 and 2.96 +/- 0.79 in the cases.
This study revealed that there was an increased oxidative stress and a decreased antioxidant defense in patients with rheumatoid arthritis.
类风湿关节炎（RA）是一种病因不明的慢性多系统疾病。疾病活动导致活性氧和脂质过氧化物的形成可能发挥重要作用。氧化应激和抗氧化状态的降低是近年来 RA 患者的特征。本研究的目的是通过测量丙二醛来确定氧化应激，通过估计超氧化物歧化酶和谷胱甘肽还原酶来评估酶抗氧化状态，然后将 RA 患者与健康个体进行比较。
本研究包括 2007 年 9 月至 2008 年 8 月在印度南部 Belgaum 的 KLE 学会 Prabhakar Kore 医院和研究中心就诊的 40 例临床诊断和实验室确诊的 RA 患者。所有患者年龄在 40-60 岁之间，包括男女。在病例（40 例）和对照组（40 例）中评估了生化参数如丙二醛、酶抗氧化剂如超氧化物歧化酶和谷胱甘肽还原酶。
对照组血液丙二醛（nmol/ml）的平均水平为 6.19 +/- 0.96，病例组为 11.48 +/- 0.76。对照组超氧化物歧化酶（IU/gHb）的平均水平为 948.32 +/- 99.88，病例组为 443.68 +/- 111.69。对照组谷胱甘肽还原酶水平（IU/gHb）的平均水平为 8.91 +/- 1.04，病例组为 2.96 +/- 0.79。
本研究表明，类风湿关节炎患者存在氧化应激增加和抗氧化防御降低。
