Zhang Zaiyu, Yi Xiaohui, Ding Yumei
Department of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Division of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Heliyon. 2024 Jun 10;10(12):e32644. doi: 10.1016/j.heliyon.2024.e32644. eCollection 2024 Jun 30.
Oral lichen planus (OLP) is a T cell-mediated autoimmune disease that affects the oral mucosa. Although has been documented in subgingival and supragingival plaques and saliva, little is currently known about the relationship between and OLP, warranting further research.
PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Web of Science databases were thoroughly searched for relevant articles published from inception until May 23, 2023.
Due to high heterogeneity among the included studies (Tau = 2.16; = 40.33, df = 6; = 85 %), we employed a random-effects model (REM). The forest plot revealed a significant correlation between infection and OLP, with an odds ratio (OR) of 4.69 (95 % CI: 1.36 to 16.19; < 0.01). Sensitivity analysis showed that the pooled ORs ranged from 3.69 (95 % CI: 1.01 to 13.44; = 0.05) to 6.77 (95 % CI: 2.65-17.30; < 0.001), and no single study significantly influenced the results when removed individually. Additionally, subgroup analysis was conducted to investigate the relationship between infection and OLP and explore the sources of heterogeneity. Finally, Begg's test ( = 0.24) and Egger's test ( = 0.35) were performed on the included studies, and the results indicated no significant publication bias.
Our meta-analysis suggests a close association between infection and OLP. Nevertheless, further research is warranted to validate these results in the future.
口腔扁平苔藓（OLP）是一种影响口腔黏膜的T细胞介导的自身免疫性疾病。虽然[某种微生物]已在龈下和龈上菌斑及唾液中被记录，但目前对其与OLP之间的关系知之甚少，需要进一步研究。
全面检索了PubMed、Embase、中国知网（CNKI）和Web of Science数据库，以查找从创刊至2023年5月23日发表的相关文章。
由于纳入研究之间存在高度异质性（Tau = 2.16；I² = 40.33，自由度 = 6；P = 85%），我们采用了随机效应模型（REM）。森林图显示[某种微生物]感染与OLP之间存在显著相关性，优势比（OR）为4.69（95%置信区间：1.36至16.19；P < 0.01）。敏感性分析表明，合并后的OR范围为3.69（95%置信区间：1.01至13.44；P = 0.05）至6.77（95%置信区间：2.65 - 17.30；P < 0.001），并且在单独剔除任何一项研究时，没有一项研究对结果产生显著影响。此外，进行了亚组分析以研究[某种微生物]感染与OLP之间的关系并探索异质性来源。最后，对纳入研究进行了Begg检验（P = 0.24）和Egger检验（P = 0.35），结果表明不存在显著的发表偏倚。
我们的荟萃分析表明[某种微生物]感染与OLP之间存在密切关联。然而，未来仍需要进一步研究来验证这些结果。
