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绝经类型、激素治疗使用模式与潮热

Type of menopause, patterns of hormone therapy use, and hot flashes.

作者信息

Gallicchio Lisa, Whiteman Maura K, Tomic Dragana, Miller Kimberly P, Langenberg Patricia, Flaws Jodi A

机构信息

Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

出版信息

Fertil Steril. 2006 May;85(5):1432-40. doi: 10.1016/j.fertnstert.2005.10.033. Epub 2006 Mar 29.

DOI:10.1016/j.fertnstert.2005.10.033
PMID:16566933
Abstract

OBJECTIVE

To examine the associations between the type of menopause (natural, hysterectomy with ovarian conservation, and hysterectomy with bilateral oophorectomy) and the experiencing of hot flashes while accounting for different patterns of hormone therapy (HT) use among the menopausal groups.

DESIGN

Cross-sectional study.

SETTING

Women who reported their history of hot flashes and HT use through a mailed survey.

PATIENT(S): Postmenopausal women ages 40-60 years residing in the Baltimore metropolitan area.

INTERVENTION(S): No interventions were administered.

MAIN OUTCOME MEASURE(S): Associations between type of menopause and the experiencing of hot flashes.

RESULT(S): Among all participants, both types of surgical menopause were associated with a decreased risk of experiencing any, moderate or severe, and daily hot flashes. After taking into account HT use patterns, women who underwent bilateral oophorectomy were at increased risk of experiencing any, moderate or severe, and daily hot flashes compared with women with natural menopause, although only the results for moderate or severe hot flashes were statistically significant. Women who underwent hysterectomy with ovarian conservation remained at significantly lower odds of experiencing any hot flashes than women with natural menopause.

CONCLUSION(S): Women who undergo bilateral oophorectomy and who are not given HT to prevent the onset of menopausal symptoms are at increased risk of experiencing hot flashes, especially those that are moderate to severe in nature, compared with women with natural menopause.

摘要

目的

在考虑绝经组中不同激素疗法(HT)使用模式的情况下,研究绝经类型(自然绝经、保留卵巢的子宫切除术和双侧卵巢切除术的子宫切除术)与潮热体验之间的关联。

设计

横断面研究。

地点

通过邮寄调查问卷报告潮热病史和HT使用情况的女性。

患者

居住在巴尔的摩都会区的40 - 60岁绝经后女性。

干预措施

未实施干预措施。

主要观察指标

绝经类型与潮热体验之间的关联。

结果

在所有参与者中,两种手术绝经类型均与经历任何程度、中度或重度以及每日潮热的风险降低相关。在考虑HT使用模式后,与自然绝经的女性相比,接受双侧卵巢切除术的女性经历任何程度、中度或重度以及每日潮热的风险增加,尽管只有中度或重度潮热的结果具有统计学意义。保留卵巢的子宫切除术的女性经历任何潮热的几率仍显著低于自然绝经的女性。

结论

与自然绝经的女性相比,接受双侧卵巢切除术且未接受HT以预防绝经症状发作的女性经历潮热的风险增加,尤其是中度至重度潮热。

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