阿托伐他汀治疗对异丙肾上腺素诱导的大鼠心肌梗死的影响。
Effect of atorvastatin treatment on isoproterenol-induced myocardial infarction in rats.
作者信息
Trivedi Chitrang J, Balaraman R, Majithiya Jayesh B, Bothara Sunil B
机构信息
Pharmacy Department, Faculty of Technology and Engineering, M.S. University of Baroda, Kalabhavan, Baroda, Gujarat, India.
出版信息
Pharmacology. 2006;77(1):25-32. doi: 10.1159/000092308. Epub 2006 Mar 27.
In the present study, chronic treatment of atorvastatin was evaluated on isoproterenol-induced myocardial infarction. Male Sprague-Dawley rats (200 +/- 25 g) were randomized into the following four groups: (1) control group, (2) isoproterenol-treated group, (3) atorvastatin-treated group, and (4) isoproterenol- and atorvastatin-treated group. Various serum and tissue parameters as well as histopathological studies were carried out in all groups. Isoproterenol administration produced severe myocardial damage and oxidative stress in rats. Atorvastatin treatment reduced myocardial infarction which has been reflected by improvement in serum parameters, ATPase activities and histopathological lesions. However, it could not reduce oxidative stress and hypertrophy induced by isoproterenol. Hence, it can be concluded that atorvastatin may protect myocardial infarction induced by isoproterenol independent of its antioxidant properties.
在本研究中，评估了阿托伐他汀长期治疗对异丙肾上腺素诱导的心肌梗死的影响。将雄性Sprague-Dawley大鼠（200±25克）随机分为以下四组：（1）对照组，（2）异丙肾上腺素治疗组，（3）阿托伐他汀治疗组，以及（4）异丙肾上腺素和阿托伐他汀联合治疗组。对所有组进行了各种血清和组织参数以及组织病理学研究。给予异丙肾上腺素会导致大鼠严重的心肌损伤和氧化应激。阿托伐他汀治疗减少了心肌梗死，这已通过血清参数、ATP酶活性和组织病理学损伤的改善得到体现。然而，它不能降低异丙肾上腺素诱导的氧化应激和肥大。因此，可以得出结论，阿托伐他汀可能独立于其抗氧化特性保护异丙肾上腺素诱导的心肌梗死。
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