Perucci C A, Davoli M, Rapiti E, Abeni D D, Forastiere F
Epidemiology Unit, Regional Health Authority, Rome, Italy.
Am J Public Health. 1991 Oct;81(10):1307-10. doi: 10.2105/ajph.81.10.1307.
A historical cohort study was carried out in Rome to examine overall and cause-specific mortality among intravenous drug users (IVDUs). A total of 4200 IVDUs (3411 men and 789 women) enrolled in methadone treatment centers between 1980 and 1988 were studied. There were 239 deaths during the follow-up period. The overall SMR was 10.10 in the entire cohort (95% confidence interval, 8.86-11.47), 9.30 in males and 18.07 in females. A large excess of mortality in both sexes was found for infectious, circulatory, respiratory, and digestive diseases as well as for violence, overdose, AIDS, and unknown or ill-defined causes. Tumors and suicide were excessive only in males. Deaths due to drug overdose, violence or trauma, and cirrhosis accounted for 63.6%, AIDS for 7.1%, endocarditis and other bacterial infections for 7.1%, and neoplasms for 3.8% of total mortality. These findings document serious health consequences of drug abuse in Italy.
在罗马开展了一项历史性队列研究，以调查静脉吸毒者的全因死亡率和特定病因死亡率。对1980年至1988年间在美沙酮治疗中心登记的4200名静脉吸毒者（3411名男性和789名女性）进行了研究。随访期间共有239人死亡。整个队列的标准化死亡比（SMR）为10.10（95%置信区间，8.86 - 11.47），男性为9.30，女性为18.07。发现男女在传染病、循环系统疾病、呼吸系统疾病、消化系统疾病以及暴力、药物过量、艾滋病和不明或定义不明确的病因方面死亡率大幅过高。肿瘤和自杀仅在男性中过高。药物过量、暴力或创伤以及肝硬化导致的死亡占总死亡率的63.6%，艾滋病占7.1%，心内膜炎和其他细菌感染占7.1%，肿瘤占3.8%。这些发现证明了意大利药物滥用造成的严重健康后果。
