Rouzet P, Rubie H, Robert A, Dutour A, Olives J P, Scipioni C, Guitard J, Régnier C
Unité d'Hémato-Oncologie Pédiatrique, CHRU Purpan, Toulouse.
Arch Fr Pediatr. 1991 Jun-Jul;48(6):423-6.
Two cases of children treated for malignant tumor and who developed a severe lacticacidosis are reported. A 2 year-old girl and a 8 year-old boy were treated with chemotherapy, irradiation and multiple surgical procedures for nephroblastoma and lymphoma respectively. These two malnourished patients, under exclusive parenteral nutrition for two weeks without vitamin intakes, suddenly developed neurological, cardiovascular and digestive symptoms, associated with cytopenia and lacticacidosis. Injection of vitamin B1 only corrected these abnormalities within a few hours, proving the role of thiamine deficiency as the cause of the symptoms.
报告了两例接受恶性肿瘤治疗并发生严重乳酸酸中毒的儿童病例。一名2岁女孩和一名8岁男孩分别因肾母细胞瘤和淋巴瘤接受化疗、放疗及多次外科手术。这两名营养不良的患者在仅接受肠外营养两周且未摄入维生素的情况下，突然出现神经、心血管和消化系统消化症状，并伴有血细胞减少和乳酸酸中毒。仅注射维生素B1在数小时内就纠正了这些异常，证明硫胺素缺乏是症状的病因。
