使用他克莫司（FK506）进行免疫治疗不会在肝移植患者的白色念珠菌分离株中选择对钙调神经磷酸酶抑制剂产生耐药性。
Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients.
作者信息
Reedy Jennifer L, Husain Shahid, Ison Michael, Pruett Timothy L, Singh Nina, Heitman Joseph
机构信息
Department of Molecular Genetics and Microbiology, 322 CARL Building, Box 3546, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
出版信息
Antimicrob Agents Chemother. 2006 Apr;50(4):1573-7. doi: 10.1128/AAC.50.4.1573-1577.2006.
Abstract
In Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candida isolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.
摘要
在白色念珠菌中，钙调神经磷酸酶介导对唑类抗真菌药物的耐受性、在血清中的存活能力及毒力。在本研究中，我们检测了24株来自接受钙调神经磷酸酶抑制剂作为免疫抑制治疗一部分的肝移植受者的念珠菌分离株。我们未能在这些分离株中检测到钙调神经磷酸酶抑制剂与氟康唑、血清或钙联合使用时敏感性的差异。
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