Kelesidis I, Kelesidis T, Mantzoros C S
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Br J Cancer. 2006 May 8;94(9):1221-5. doi: 10.1038/sj.bjc.6603051.
Recent studies have demonstrated that obesity is a significant risk factor for the development of several malignancies, but the mechanisms underlying this relationship remain to be fully elucidated. Adiponectin, an adipocyte secreted endogenous insulin sensitizer, appears to play an important role not only in glucose and lipid metabolism but also in the development and progression of several obesity-related malignancies. In this review, we present recent findings on the association of adiponectin with several malignancies as well as recent data on underlying molecular mechanisms that provide novel insights into the association between obesity and cancer risk. We also identify important research questions that remain unanswered.
近期研究表明，肥胖是多种恶性肿瘤发生的重要危险因素，但这种关系背后的机制仍有待充分阐明。脂联素是一种由脂肪细胞分泌的内源性胰岛素增敏剂，似乎不仅在葡萄糖和脂质代谢中发挥重要作用，而且在几种与肥胖相关的恶性肿瘤的发生和发展中也发挥重要作用。在本综述中，我们介绍了脂联素与几种恶性肿瘤关联的最新研究结果，以及关于潜在分子机制的最新数据，这些数据为肥胖与癌症风险之间的关联提供了新的见解。我们还确定了尚未得到解答的重要研究问题。
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