Wolters U, Mannheim S, Wassmer G, Brunkwall J
Department of Vascular and Thoracic Surgery, St. Katharinen Hospital Frechen, Academic Hospital University of Cologne, Germany.
J Cardiovasc Surg (Torino). 2006 Apr;47(2):177-85.
With an aging population, atherosclerotic manifestations are steadily increasing. Beside the anatomical and pathophysiological preoperative risk-factors accompanying perioperative risk-factors like patient's age, length of operation, blood loss and skill of the surgeon, all need to be accounted for when assessing the risk of morbidity and mortality after vascular surgery. The demand for cost effectiveness may make a risk-score system useful. The aim of the present study was, therefore, to prospectively apply various scoring systems in order to estimate outcome in patients undergoing aortobifemoral surgery due to arterial occlusive disease at the aorto-iliac level.
A prospective non randomized study was carried out. The SPSS 9.0 statistical package for Windows and, for nominal data, chi-squared-tests were used to compare rates between groups. For continuous data analysis of variance (ANOVA) was performed. When appropriate, a multivariate analysis with binary-regression by Wald was used. Sensitivity and specificity was done using ROC-curves. P < 0.05 was considered significant. From May 1996 to June 2000, 107 patients were included in the study. Besides basic data, all postoperative complications were noted according to a specific definition. Four different risk-scoring systems were used: ASA-classification; the acute physiology and chronic health evaluation (APACHE-II) system; the physiological and operative severity score for enumeration of mortality and morbidity (POSSUM) classification and, finally, the simplified acute physiology score (SAPS) classification.
We found no significant correlation between risk-scores and outcome. None of the scoring systems used was able to predict mortality. The independent factors that influenced the postoperative complication rate were operating time, blood loss, intraoperative assisted ventilation time and age. The endpoint using the relative operating characteristic (ROC) curves analysis was either mortality or morbidity.
It can be concluded that none of the systems analyzed separately was useful for determining morbidity and mortality. We still lack a system, that can be used preoperatively in an individual case and the vascular surgeon still has to build up his own clinical judgement or to transfer a clinical judgement.
随着人口老龄化,动脉粥样硬化表现正稳步增加。除了解剖学和病理生理学方面的术前危险因素外,围手术期危险因素如患者年龄、手术时长、失血量及外科医生的技术水平等,在评估血管手术后发病和死亡风险时都需要考虑在内。对成本效益的需求可能使风险评分系统变得有用。因此,本研究的目的是前瞻性地应用各种评分系统,以评估因主-髂动脉水平动脉闭塞性疾病而接受主-双股动脉手术患者的预后。
进行了一项前瞻性非随机研究。使用适用于Windows的SPSS 9.0统计软件包,对于名义数据,采用卡方检验比较组间率。对于连续数据,进行方差分析(ANOVA)。在适当情况下,使用Wald二元回归进行多变量分析。使用ROC曲线计算敏感性和特异性。P < 0.05被认为具有统计学意义。从1996年5月至2000年6月,107例患者纳入本研究。除基本数据外,所有术后并发症均根据特定定义进行记录。使用了四种不同的风险评分系统:美国麻醉医师协会(ASA)分级;急性生理与慢性健康评估(APACHE-II)系统;用于计算死亡率和发病率的生理和手术严重程度评分(POSSUM)分级,以及简化急性生理学评分(SAPS)分级。
我们发现风险评分与预后之间无显著相关性。所使用的评分系统均无法预测死亡率。影响术后并发症发生率的独立因素为手术时间、失血量、术中辅助通气时间及年龄。使用相对手术特征(ROC)曲线分析的终点为死亡率或发病率。
可以得出结论,单独分析的这些系统均无助于确定发病率和死亡率。我们仍然缺乏一种可在个体病例术前使用的系统,血管外科医生仍需建立自己的临床判断或借鉴他人的临床判断。