Karlskov-Mortensen P, Bruun C S, Braunschweig M H, Sawera M, Markljung E, Enfält A C, Hedebro-Velander I, Josell A, Lindahl G, Lundström K, von Seth G, Jørgensen C B, Andersson L, Fredholm M
Division of Genetics, Department of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Anim Genet. 2006 Apr;37(2):156-62. doi: 10.1111/j.1365-2052.2005.01405.x.
We report the identification of quantitative trait loci (QTL) affecting carcass composition, carcass length, fat deposition and lean meat content using a genome scan across 462 animals from a combined intercross and backcross between Hampshire and Landrace pigs. Data were analysed using multiple linear regression fitting additive and dominance effects. This model was compared with a model including a parent-of-origin effect to spot evidence of imprinting. Several precisely defined muscle phenotypes were measured in order to dissect body composition in more detail. Three significant QTL were detected in the study at the 1% genome-wide level, and twelve significant QTL were detected at the 5% genome-wide level. These QTL comprise loci affecting fat deposition and lean meat content on SSC1, 4, 9, 10, 13 and 16, a locus on SSC2 affecting the ratio between weight of meat and bone in back and weight of meat and bone in ham and two loci affecting carcass length on SSC12 and 17. The well-defined phenotypes in this study enabled us to detect QTL for sizes of individual muscles and to obtain information of relevance for the description of the complexity underlying other carcass traits.
我们报告了利用基因组扫描，在汉普夏猪和长白猪杂交与回交产生的462只后代中，鉴定出影响胴体组成、胴体长度、脂肪沉积和瘦肉含量的数量性状基因座（QTL）。使用拟合加性和显性效应的多元线性回归分析数据。将该模型与包含亲本来源效应的模型进行比较，以发现印记证据。为了更详细地剖析身体组成，测量了几种精确界定的肌肉表型。在该研究中，在全基因组水平1%时检测到3个显著的QTL，在全基因组水平5%时检测到12个显著的QTL。这些QTL包括位于1号、4号、9号、10号、13号和16号猪染色体（SSC）上影响脂肪沉积和瘦肉含量的基因座，位于2号SSC上影响背部肉骨重量与火腿肉骨重量之比的一个基因座，以及位于12号和17号SSC上影响胴体长度的两个基因座。本研究中明确界定的表型使我们能够检测到个体肌肉大小的QTL，并获得与描述其他胴体性状潜在复杂性相关的信息。
