β2肾上腺素能受体的Glu27基因型是严重冠状动脉疾病的预测指标。

The Glu27 genotypes of the beta2-adrenergic receptor are predictors for severe coronary artery disease.

作者信息

Abu-Amero Khaled K, Al-Boudari Olayan M, Mohamed Gamal H, Dzimiri Nduna

机构信息

Genetics Department, King Faisal Specialist Hospital and Research Centre (MBC - 03), P. O. Box 3354, Riyadh 11211, Saudi Arabia.

出版信息

BMC Med Genet. 2006 Mar 30;7:31. doi: 10.1186/1471-2350-7-31.

DOI:10.1186/1471-2350-7-31

PMID:16573811

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1481543/

Abstract

BACKGROUND

The role of the Beta2-adrenoceptor (beta2-AR) Gln27Glu polymorphism in the manifestation of cardiovascular diseases is still unclear.

METHODS

In the present study, we evaluated the potential relevance of the c.79 C>G (p.Gln27Glu) polymorphism of this receptor gene for coronary artery disease (CAD) and its associated risk factors in Saudi Arabs. Genotyping was performed by PCR using the confronting two-pair primer (PCR-CTPP) method.

RESULTS

In the general population group (BD) (n = 895), 68.5% were homozygous wild-type C/C, 28.3% were heterozygous C/G and 3.2% were homozygous mutant G/G. Among the CAD patients (n = 773), 50.6% were homozygous wild-type C/C, 43.6% were heterozygous C/G and 5.8% were homozygous mutant G/G, while in the angiographed control group (CON) (n = 528), 71.8% were C/C, 24.4% C/G and 3.8% G/G genotypes. These results indicate that both the C/G (p = or < .001) and G/G (p = .005) genotypes are significantly associated with CAD, when compared to the CON group. In addition, C/G (p = or < .001) and G/G (p = or < .001) were significantly associated with CAD, when compared to the BD group. Furthermore, stepwise logistic regression showed that the genotype [C/G (p < .001) and G/G (p < .001)] increase the risk of CAD.

CONCLUSION

These results shows that the Gln27Glu genotypes (homo- or heterozygous) of the beta2-AR may be independent predictors of severe CAD.

摘要

背景

β2肾上腺素能受体（β2-AR）Gln27Glu多态性在心血管疾病表现中的作用仍不清楚。

方法

在本研究中，我们评估了该受体基因的c.79 C>G（p.Gln27Glu）多态性与沙特阿拉伯人冠状动脉疾病（CAD）及其相关危险因素的潜在相关性。采用两对引物对撞PCR（PCR-CTPP）方法进行基因分型。

结果

在普通人群组（BD）（n = 895）中，68.5%为纯合野生型C/C，28.3%为杂合子C/G，3.2%为纯合突变型G/G。在CAD患者（n = 773）中，50.6%为纯合野生型C/C，43.6%为杂合子C/G，5.8%为纯合突变型G/G，而在血管造影对照组（CON）（n = 528）中，71.8%为C/C基因型，24.4%为C/G基因型，3.8%为G/G基因型。这些结果表明，与CON组相比，C/G（p≤0.001）和G/G（p = 0.005）基因型均与CAD显著相关。此外，与BD组相比，C/G（p≤0.001）和G/G（p≤0.001）也与CAD显著相关。此外，逐步逻辑回归显示，基因型[C/G（p < 0.001）和G/G（p < 0.001）]增加了CAD风险。