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1998年新西兰公立医院住院病例系列报道——第三部分:不良事件与死亡情况

Representative case series from New Zealand public hospital admissions in 1998--III: adverse events and death.

作者信息

Briant Robin, Buchanan John, Lay-Yee Roy, Davis Peter

机构信息

Centre for Health Services Research and Policy, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

出版信息

N Z Med J. 2006 Mar 31;119(1231):U1909.

Abstract

AIMS

To examine a representative series of adverse events in New Zealand public hospitals where death was the final outcome recorded, with a view to determining the relationship between adverse event and death.

METHODS

A review was carried out of the 38 adverse events (AEs) in the New Zealand Quality of Healthcare Study where death was the outcome, and categories of relationship were established. These were identified from the total of 850 AEs determined by two-stage retrospective review of a representative sample of 6579 medical records drawn from 13 NZ public hospitals in 1998. A stricter definition of AEs, comparable with American studies, was then applied to estimate rates of death associated with AEs.

RESULTS

There were 118 deaths at discharge identified in the sample of medical records, giving a rate of 18.0 deaths per 1000 admissions overall. A total of 30 deaths, either at or after discharge, were associated with AEs (4.6 per 1000 admissions); 19 being judged attributable to the AE either "definitely" (10) or probably (9), giving a combined rate of 2.8 AE-attributable deaths per 1000 admissions. The "definite" group had an age, comorbidity, and added-bed-days profile that was close to the average for all deaths associated with an AE. The "probable" group departed from this profile in being younger, exhibiting higher comorbidity, and having twice the added bed-days. Based on population life tables, the average years of life lost was 11.8 years for the definite group and 25.0 years for the probable group. Assessed on the preventability of the associated AE, it was estimated that 2.2 deaths per 1000 admissions were highly preventable. However, once deaths that were not judged to be attributable to the AE were excluded, the rate reduced to 1.3 AE-preventable deaths per 1000.

CONCLUSIONS

Because of the nature of the record review procedure used in the New Zealand Quality of Healthcare Study, a finding of death did not necessarily mean that an adverse event and death were causally related. Indeed, it is possible that extrapolations of mortality rates in this and other similar studies over-estimate by about a half the number of deaths caused by healthcare management.

摘要

目的

研究新西兰公立医院中一系列具有代表性的不良事件,这些不良事件最终导致患者死亡,旨在确定不良事件与死亡之间的关系。

方法

对新西兰医疗质量研究中38例以死亡为结局的不良事件进行回顾,并确定了关联类别。这些事件是从1998年从13家新西兰公立医院抽取的6579份病历的代表性样本中,通过两阶段回顾性审查确定的总共850例不良事件中识别出来的。然后采用与美国研究相当的更严格的不良事件定义,以估计与不良事件相关的死亡率。

结果

在病历样本中,出院时共有118例死亡,总体每1000例入院患者中有18.0例死亡。共有30例出院时或出院后死亡与不良事件相关(每1000例入院患者中有4.6例);其中19例被判定“肯定”(10例)或“可能”(9例)归因于不良事件,每1000例入院患者中归因于不良事件的死亡综合发生率为2.8例。“肯定”组的年龄、合并症和额外住院天数情况与所有与不良事件相关的死亡的平均情况相近。“可能”组则不同,该组患者更年轻,合并症更多,额外住院天数是前者的两倍。根据人口生命表,“肯定”组平均寿命损失11.8年,“可能”组为25.0年。根据相关不良事件的可预防性评估,估计每100例入院患者中有2.2例死亡是高度可预防的。然而,一旦排除那些不被判定归因于不良事件的死亡,该发生率降至每1000例中有1.3例可通过不良事件预防的死亡。

结论

由于新西兰医疗质量研究中使用的记录审查程序的性质,死亡的发现并不一定意味着不良事件与死亡存在因果关系。实际上,本研究及其他类似研究中死亡率的推断可能高估了医疗管理导致的死亡人数约一半。

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