Vermetten Eric, Schmahl Christian, Lindner Sanneke, Loewenstein Richard J, Bremner J Douglas
Department of Psychiatry, Rudolf Magnus Institute of Neurosciences, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Am J Psychiatry. 2006 Apr;163(4):630-6. doi: 10.1176/ajp.2006.163.4.630.
Smaller hippocampal volume has been reported in several stress-related psychiatric disorders, including posttraumatic stress disorder (PTSD), borderline personality disorder with early abuse, and depression with early abuse. Patients with borderline personality disorder and early abuse have also been found to have smaller amygdalar volume. The authors examined hippocampal and amygdalar volumes in patients with dissociative identity disorder, a disorder that has been associated with a history of severe childhood trauma.
The authors used magnetic resonance imaging to measure the volumes of the hippocampus and amygdala in 15 female patients with dissociative identity disorder and 23 female subjects without dissociative identity disorder or any other psychiatric disorder. The volumetric measurements for the two groups were compared.
Hippocampal volume was 19.2% smaller and amygdalar volume was 31.6% smaller in the patients with dissociative identity disorder, compared to the healthy subjects. The ratio of hippocampal volume to amygdalar volume was significantly different between groups.
The findings are consistent with the presence of smaller hippocampal and amygdalar volumes in patients with dissociative identity disorder, compared with healthy subjects.
已有报道称，在几种与应激相关的精神障碍中，海马体体积较小，包括创伤后应激障碍（PTSD）、伴有早期虐待史的边缘型人格障碍以及伴有早期虐待史的抑郁症。还发现，伴有早期虐待史的边缘型人格障碍患者杏仁核体积较小。作者研究了分离性身份障碍患者的海马体和杏仁核体积，该障碍与严重童年创伤史有关。
作者使用磁共振成像测量了15名分离性身份障碍女性患者以及23名无分离性身份障碍或任何其他精神障碍的女性受试者的海马体和杏仁核体积。对两组的体积测量结果进行了比较。
与健康受试者相比，分离性身份障碍患者的海马体体积小19.2%，杏仁核体积小31.6%。两组之间海马体体积与杏仁核体积的比率存在显著差异。
研究结果表明，与健康受试者相比，分离性身份障碍患者的海马体和杏仁核体积较小。
