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Dose-dependent effect of alcohol on insulin-like growth factor systems in male rats.酒精对雄性大鼠胰岛素样生长因子系统的剂量依赖性效应。
Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):22-8. doi: 10.1111/j.1440-1681.2004.03945.x.
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Ethanol-induced hepatotoxicity and protective effect of betaine.乙醇诱导的肝毒性及甜菜碱的保护作用
Cell Biochem Funct. 2001 Dec;19(4):281-5. doi: 10.1002/cbf.926.
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Insulin-like growth factor (IGF)-1 and IGF-binding protein-1 concentrations in serum of normal subjects after alcohol ingestion: evidence for decreased IGF-1 bioavailability.正常受试者饮酒后血清中胰岛素样生长因子（IGF）-1和IGF结合蛋白-1浓度：IGF-1生物利用度降低的证据。
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Potentiation of mitogen-activated protein kinase by ethanol in embryonic liver cells.乙醇对胚胎肝细胞中丝裂原活化蛋白激酶的增强作用。
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S-adenosylmethionine generation and prevention of alcoholic fatty liver by betaine.甜菜碱生成S-腺苷甲硫氨酸并预防酒精性脂肪肝
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Ethanol induces a paradoxical simultaneous increase in circulating concentrations of insulin-like growth factor binding protein-1 and insulin.乙醇会引起循环中胰岛素样生长因子结合蛋白-1和胰岛素浓度同时出现反常升高。
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甜菜碱对大鼠原代肝细胞中乙醇刺激的IGF-I和IGFBP-1分泌的影响：p42/44 MAPK激活的参与

Effects of betaine on ethanol-stimulated secretion of IGF-I and IGFBP-1 in rat primary hepatocytes: involvement of p42/44 MAPK activation.

作者信息

Lee Myeong Soo, Kim Myung-Sunny, Park Soo Young, Kang Chang-Won

机构信息

Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter EX2 4NT, United Kingdom.

出版信息

World J Gastroenterol. 2006 Mar 21;12(11):1718-22. doi: 10.3748/wjg.v12.i11.1718.

DOI:10.3748/wjg.v12.i11.1718
PMID:16586540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4124346/
Abstract

AIM

To evaluate the effects of betaine on the ethanol-induced secretion of IGF-I and IGFBP-1 using radioimmunoassay and Western blotting, respectively, in primary cultured rat hepatocytes.

METHODS

Hepatocytes isolated from male Sprague-Dawley rats were incubated with various concentrations of ethanol and PD98059 procedures. The hepatocytes were also treated with different doses of betaine (10(-5), 10(-4), and 10(-3) mol/L). We measured IGF-I and IGFBP-1 using radioimmunoassay and Western blotting, respectively.

RESULTS

The ethanol-induced inhibition of IGF-I secretion was attenuated by betaine in a concentration-dependent manner in primary cultured rat hepatocytes. At 10(-3) mol/L, betaine significantly increased IGF-I secretion but decreased IGFBP-1 secretion. In addition, p42/44 mitogen-activated protein kinase (MAPK) activity was accelerated significantly from 10 min to 5 h after treatment with 10(-3) mol/L betaine. Furthermore, the changes in IGF-1 and IGFBP-1 secretion resulting from the increased betaine-induced p42/44 MAPK activity in primary cultured rat hepatocytes was blocked by treatment with the MAPK inhibitor PD98059. Betaine treatment blocked the ethanol-induced inhibition of IGF-I secretion and p42/44 MAPK activity, and the ethanol-induced increase in IGFBP-1 secretion.

CONCLUSION

Betaine modulates the secretion of IGF-I and IGFBP-1 via the activation of p42/44 MAPK in primary cultured rat hepatocytes. Betaine also alters the MAPK activations induced by ethanol.

摘要

目的

分别采用放射免疫分析法和蛋白质免疫印迹法，评估甜菜碱对原代培养大鼠肝细胞中乙醇诱导的胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白-1（IGFBP-1）分泌的影响。

方法

将从雄性Sprague-Dawley大鼠分离的肝细胞与不同浓度的乙醇及PD98059进行孵育。肝细胞还分别用不同剂量的甜菜碱（10⁻⁵、10⁻⁴和10⁻³mol/L）处理。我们分别采用放射免疫分析法和蛋白质免疫印迹法检测IGF-I和IGFBP-1。

结果

在原代培养的大鼠肝细胞中，甜菜碱以浓度依赖的方式减弱了乙醇诱导的IGF-I分泌抑制作用。在10⁻³mol/L时，甜菜碱显著增加IGF-I分泌，但降低IGFBP-1分泌。此外，在用10⁻³mol/L甜菜碱处理后10分钟至5小时，p42/44丝裂原活化蛋白激酶（MAPK）活性显著加快。此外，原代培养大鼠肝细胞中甜菜碱诱导的p42/44 MAPK活性增加所导致的IGF-1和IGFBP-1分泌变化，被MAPK抑制剂PD98059处理所阻断。甜菜碱处理阻断了乙醇诱导的IGF-I分泌抑制和p42/44 MAPK活性，以及乙醇诱导的IGFBP-1分泌增加。

结论

在原代培养的大鼠肝细胞中，甜菜碱通过激活p42/44 MAPK调节IGF-I和IGFBP-1的分泌。甜菜碱还改变了乙醇诱导的MAPK激活。