Sowers J R, Khoury S
Division of Endocrinology, Wayne State University School of Medicine, Detroit, Michigan.
Prim Care. 1991 Sep;18(3):509-24.
The basic mechanisms that initiate and sustain hypertension in type 2 diabetics are poorly understood. Contributing factors discussed in this review include obesity, insulin resistance, hyperinsulinemia, genetic factors, and abnormalities of cellular cation homeostasis. Also discussed are the features of hypertension in type 2 diabetic individuals that are reminiscent of the hemodynamic abnormalities characterizing hypertension in the elderly, including increased vascular reactivity and increased atherosclerotic vascular disease. This article reviews mechanisms by which hyperinsulinemia, insulin resistance, or both may lead to hypertension.
引发和维持2型糖尿病患者高血压的基本机制目前仍知之甚少。本综述中讨论的促成因素包括肥胖、胰岛素抵抗、高胰岛素血症、遗传因素以及细胞阳离子稳态异常。文中还讨论了2型糖尿病患者高血压的特征，这些特征让人联想到老年人高血压所具有的血流动力学异常，包括血管反应性增加和动脉粥样硬化性血管疾病增多。本文综述了高胰岛素血症、胰岛素抵抗或两者兼而有之可能导致高血压的机制。
