艾氏剂对大鼠副性腺及血浆睾酮水平的影响。
Effect of aldrin on accessory sex glands and plasma testosterone levels in rats.
作者信息
Chatterjee S, Ray A, Deb C, Gosh S, Kabir S N, Pakrashi A
机构信息
Department of Physiology, Calcutta University, India.
出版信息
Andrologia. 1988 Nov-Dec;20(6):472-6.
The effects of aldrin, an organochlorine insecticide, on accessory sex glands and plasma testosterone levels in rats were studied. The aldrin was administered i.p. for 13 days and 26 days at a dose of 150 micrograms/kg. Relative weights of prostate, seminal vesicles and coagulating glands were significantly decreased in the treated rats compared to those in controls. In addition, there was a significant fall in acid phosphatase activity in prostate and fructose content in accessory sex glands was also observed in treated animals. Plasma testosterone values showed a decrease with the duration of treatment. HCG supplementation with aldrin treatment prevented all those untoward effects of aldrin in experimental rats.
研究了有机氯杀虫剂艾氏剂对大鼠附属性腺及血浆睾酮水平的影响。以150微克/千克的剂量腹腔注射艾氏剂，持续13天和26天。与对照组相比，经处理的大鼠前列腺、精囊和凝固腺的相对重量显著降低。此外，在经处理的动物中还观察到前列腺酸性磷酸酶活性显著下降，附属性腺中的果糖含量也有所降低。血浆睾酮值随治疗时间的延长而降低。在艾氏剂治疗的同时补充人绒毛膜促性腺激素（HCG）可防止艾氏剂对实验大鼠产生的所有这些不良影响。
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