Weaver Kelli E, Rozanski Elizabeth A, Mahony Orla M, Chan Daniel L, Freeman Lisa M
Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
J Vet Intern Med. 2006 Mar-Apr;20(2):234-8. doi: 10.1892/0891-6640(2006)20[234:uogali]2.0.co;2.
The goals of this study were to compare the efficacy of once-daily administered Glargine insulin to twice-daily administered Lente insulin in cats with diabetes mellitus and to describe the use of a high-protein, low-carbohydrate diet designed for the management of diabetes mellitus in cats. All cats with naturally occurring diabetes mellitus were eligible for inclusion. Baseline testing included a physical examination, serum biochemistry, urinalysis and urine culture, serum thyroxine concentration, and serum fructosamine concentration. All cats were fed the high-protein, low-carbohydrate diet exclusively. Cats were randomized to receive either 0.5 U/kg Lente insulin q12h or 0.5 U/kg Glargine insulin q24h. Re-evaluations were performed on all cats at weeks 1, 2, 4, 8, and 12, and included an assessment of clinical signs, physical examination, 16-hour blood glucose curve, and serum fructosamine concentrations. Thirteen cats completed the study (Lente, n = 7, Glargine, n = 6). There was significant improvement in serum fructosamine and glucose concentrations in all cats but there was no significant difference between the 2 insulin groups. Four of the 13 cats were in complete remission by the end of the study period (Lente, n = 3; Glargine, n = 1). The results of the study support the use of once-daily insulin Glargine or twice-daily Lente insulin in combination with a high-protein, low-carbohydrate diet for treatment of feline diabetes mellitus.
本研究的目的是比较每日一次注射甘精胰岛素与每日两次注射低精蛋白锌胰岛素对糖尿病猫的疗效，并描述一种专为管理猫糖尿病而设计的高蛋白、低碳水化合物饮食的使用情况。所有自然发生糖尿病的猫都符合纳入标准。基线检测包括体格检查、血清生化、尿液分析和尿培养、血清甲状腺素浓度以及血清果糖胺浓度。所有猫均只喂食高蛋白、低碳水化合物饮食。猫被随机分为两组，一组接受0.5 U/kg低精蛋白锌胰岛素，每12小时一次；另一组接受0.5 U/kg甘精胰岛素，每24小时一次。在第1、2、4、8和12周对所有猫进行重新评估，评估内容包括临床症状、体格检查、16小时血糖曲线以及血清果糖胺浓度。13只猫完成了研究（低精蛋白锌胰岛素组，n = 7；甘精胰岛素组，n = 6）。所有猫的血清果糖胺和血糖浓度均有显著改善，但两组胰岛素之间无显著差异。在研究期结束时，13只猫中有4只完全缓解（低精蛋白锌胰岛素组，n = 3；甘精胰岛素组，n = 1）。该研究结果支持使用每日一次的甘精胰岛素或每日两次的低精蛋白锌胰岛素，并结合高蛋白、低碳水化合物饮食来治疗猫糖尿病。
