Bertoy E H, Nelson R W, Feldman E C
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Am Vet Med Assoc. 1995 Jun 1;206(11):1729-31.
Ultralente insulin has replaced protamine zinc insulin as the treatment of choice in treatment of diabetes mellitus in cats. There is variability in effectiveness of ultralente insulin and problems with glycemic control develop in some cats. Alternative insulin preparations are sought when ultralente insulin is ineffective. Twelve cats with insulin-dependent diabetes mellitus were treated with lente insulin. Clinical signs improved in 8 cats given lente insulin every 12 hours. Lente insulin was ineffective in 4 cats. Three of these cats were subsequently found to have an insulin resistant disorder. In 1 cat, lente insulin was ineffective because of short duration of action. Lente insulin is a viable treatment alternative when ultralente insulin is ineffective in achieving glycemic control. Ultralente insulin is still the insulin of choice for the initial treatment of diabetes in cats, because of the potential to establish glycemic control with once-a-day treatment.
超长效胰岛素已取代精蛋白锌胰岛素，成为猫糖尿病治疗的首选药物。超长效胰岛素的疗效存在差异，部分猫会出现血糖控制问题。当超长效胰岛素无效时，会寻求其他胰岛素制剂。12只胰岛素依赖型糖尿病猫接受了中效胰岛素治疗。每12小时给予中效胰岛素的8只猫临床症状有所改善。中效胰岛素对4只猫无效。其中3只猫随后被发现患有胰岛素抵抗性疾病。在1只猫中，中效胰岛素无效是因为作用持续时间短。当超长效胰岛素在实现血糖控制方面无效时，中效胰岛素是一种可行的治疗选择。由于每天一次治疗有可能实现血糖控制，超长效胰岛素仍然是猫糖尿病初始治疗的首选胰岛素。
