钼催化的3-烷基氧化吲哚的不对称烯丙基化反应：应用于（-）-毒扁豆碱的形式全合成
Molybdenum-catalyzed asymmetric allylation of 3-alkyloxindoles: application to the formal total synthesis of (-)-physostigmine.
作者信息
Trost Barry M, Zhang Yong
机构信息
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
出版信息
J Am Chem Soc. 2006 Apr 12;128(14):4590-1. doi: 10.1021/ja060560j.
PMID:16594693
Abstract
The first example of Mo-catalyzed asymmetric allylation for the generation of quaternary stereocenters at a prochiral nucleophile is reported. A variety of 3-alkyl oxindoles can be alkylated with high yields and enantioselectivity. This method provides expedited access to (-)-physostigmine and its analogues.
摘要
报道了钼催化的不对称烯丙基化反应生成前手性亲核试剂上的季碳立体中心的首个实例。多种3-烷基氧化吲哚可实现高产率和对映选择性的烷基化反应。该方法为快速合成（-）-毒扁豆碱及其类似物提供了途径。
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