Kusano Shuichi, Igarashi Naoko, Sakai Shinobu, Toida Toshihiko
Fuji-Sangyou Co., Ltd., Marugame City, Japan.
Yakugaku Zasshi. 2006 Apr;126(4):297-300. doi: 10.1248/yakushi.126.297.
Chondroitin sulfate is widely distributed in animal tissues and possibly plays an important role in different types of metabolic reactions as well as protecting joints, the internal wall of blood vessels, skin, bone, etc. In cartilage, glycosaminoglycans have a protective function; in particular, chondroitin sulfate stabilizes fibrous and cellular elements of the connective tissue and, at the same time, lubricates and protects the membranes in joints. Recently, chondroitin sulfate has been used as a nutraceutical for the treatment of joint diseases such as osteoarthritis, although acidic and large molecules such as chondroitin sulfate might not be able to be absorbed through digestive apparatus such as the intestine. In this study, we investigated the effects of orally administered chondrosine derived from shark chondroitin sulfate on the uptake of inorganic (35)S sulfate into rat cartilage and found that chondrosine stimulates the incorporation of (35)S sulfate into cartilage compared with intact chondroitin sulfate.
硫酸软骨素广泛分布于动物组织中，可能在不同类型的代谢反应中发挥重要作用，同时对关节、血管内壁、皮肤、骨骼等起到保护作用。在软骨中，糖胺聚糖具有保护功能；特别是硫酸软骨素能稳定结缔组织的纤维和细胞成分，同时润滑和保护关节中的膜。最近，硫酸软骨素已被用作营养保健品来治疗骨关节炎等关节疾病，尽管像硫酸软骨素这样的酸性大分子可能无法通过肠道等消化器官被吸收。在本研究中，我们研究了口服源自鲨鱼硫酸软骨素的软骨素对大鼠软骨摄取无机（35）S硫酸盐的影响，发现与完整的硫酸软骨素相比，软骨素能刺激（35）S硫酸盐掺入软骨。
