Nakamura D, Akimoto T, Suzuki S, Kono I
Faculty of Economics, Seikei University, Tokyo, Japan.
J Sports Med Phys Fitness. 2006 Mar;46(1):152-7.
It is well known that highly trained athletes suffer from a high incidence of upper respiratory tract infections (URTI). Secretory immunoglobulin A (SIgA) is a major effector of mucosal surface protection against microorganisms causing URTI. Although several studies have investigated the relationship between falls in SIgA levels and appearance of URTI symptoms, the relationship is not yet clear.
We prospectively investigated the relationship between daily changes in SIgA and appearance of URTI symptoms in collegiate soccer players during a training period of 2 months.
Five of 12 subjects exhibited URTI symptoms during the study period. The SIgA level did not significantly decrease before appearance of URTI symptoms. However, the saliva flow rate and SIgA secretion rate tended to decrease 3 days before the appearance of URTI symptoms compared to that in the non-infection period (31.3+/-19, -42.2+/-20.6%, respectively).
We could not demonstrate a significant relationship between decreased SIgA levels and appearance of URTI symptoms during the training period. However, our findings suggest that monitoring of SIgA secretion rate may be useful for assessment of risk status of athletes for URTI.
众所周知，训练有素的运动员上呼吸道感染（URTI）的发生率很高。分泌型免疫球蛋白A（SIgA）是黏膜表面抵御引起URTI的微生物的主要效应物。尽管多项研究调查了SIgA水平下降与URTI症状出现之间的关系，但该关系尚不清楚。
我们前瞻性地研究了2个月训练期内大学生足球运动员SIgA的每日变化与URTI症状出现之间的关系。
12名受试者中有5名在研究期间出现了URTI症状。在URTI症状出现之前，SIgA水平没有显著下降。然而，与非感染期相比，在URTI症状出现前3天，唾液流速和SIgA分泌率有下降趋势（分别为31.3±19、-42.2±20.6%）。
我们未能证明训练期间SIgA水平下降与URTI症状出现之间存在显著关系。然而，我们的研究结果表明，监测SIgA分泌率可能有助于评估运动员发生URTI的风险状况。
