Alberini C M, Milekic M H, Tronel S
Department of Neuroscience, Mount Sinai School of Medicine, Box 1065, New York, NY 10029, USA.
Cell Mol Life Sci. 2006 May;63(9):999-1008. doi: 10.1007/s00018-006-6025-7.
Memories become stabilized through a time-dependent process that requires gene expression and is commonly known as consolidation. During this time, memories are labile and can be disrupted by a number of interfering events, including electroconvulsive shock, trauma and other learning or the transient effect of drugs such as protein synthesis inhibitors. Once consolidated, memories are insensitive to these disruptions. However, they can again become fragile if recalled or reactivated. Reactivation creates another time-dependent process, known as reconsolidation, during which the memory is restabilized. Here we discuss some of the questions currently debated in the field of memory consolidation and reconsolidation, the molecular and anatomical requirements for both processes and, finally, their functional relationship.
记忆通过一个依赖时间的过程得以稳定，这个过程需要基因表达，通常被称为巩固。在此期间，记忆是不稳定的，会受到许多干扰事件的破坏，包括电休克、创伤以及其他学习活动，或蛋白质合成抑制剂等药物的短暂影响。一旦巩固，记忆就对这些破坏不敏感了。然而，如果记忆被回忆或重新激活，它们可能会再次变得脆弱。重新激活会产生另一个依赖时间的过程，即重新巩固，在此期间记忆会再次稳定下来。在这里，我们讨论了当前在记忆巩固和重新巩固领域中存在争议的一些问题、这两个过程的分子和解剖学要求，以及它们最终的功能关系。
