Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center "Alexander Fleming", 16672 Vari, Greece.
Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Int J Mol Sci. 2022 Jun 8;23(12):6407. doi: 10.3390/ijms23126407.
Memory consolidation is a time-dependent process occurring over hours, days, or longer in different species and requires protein synthesis. An apparent exception is a memory type in elicited by a single olfactory conditioning episode, which ostensibly consolidates quickly, rendering it resistant to disruption by cold anesthesia a few hours post-training. This anesthesia-resistant memory (ARM), is independent of protein synthesis. Protein synthesis independent memory can also be elicited in by multiple massed cycles of olfactory conditioning, and this led to the prevailing notion that both of these operationally distinct training regimes yield ARM. Significantly, we show that, unlike ARM, massed conditioning-elicited memory remains sensitive to the amnestic treatment two hours post-training and hence it is not ARM. Therefore, there are two protein synthesis-independent memory types in .
记忆巩固是一个依赖时间的过程，在不同物种中需要数小时、数天或更长时间才能发生，并且需要蛋白质合成。一个明显的例外是由单次嗅觉条件反射引起的记忆类型，这种记忆显然会迅速巩固，使其在训练后几个小时内不受冷麻醉的干扰。这种抗麻醉记忆（ARM）不依赖于蛋白质合成。蛋白质合成不依赖的记忆也可以通过多次密集的嗅觉条件反射在 中诱发，这导致了一个流行的观点，即这两种操作上不同的训练方案都产生了 ARM。重要的是，我们表明，与 ARM 不同，密集条件反射引起的记忆在训练后两小时仍对健忘处理敏感，因此它不是 ARM。因此， 在 中有两种蛋白质合成独立的记忆类型。
